Advanced cardiovascular
NT-proBNP
Cardiac wall-stress marker; rules out heart failure with high NPV.
Sample
Serum or plasma
Clinical reference range
— to 300 pg/mL
Rule-out HF (<50 y, acute)
Conv: —–300 pg/mL
Biology
What it measures
Cleavage product of proBNP from ventricular myocytes in response to stretch.
Clinical use
Why we order it
Acute dyspnea triage, HF prognosis, monitor therapy.
Lens · Clinical
Interpretation by lens
Clinical interpretation
Acute thresholds (NT-proBNP): <300 rules out HF; age-adjusted in-rule values 450/900/1800 for <50, 50–75, >75.
Pitfalls
Pre-analytic & interpretation traps
- !Higher in elderly, CKD, AF; lower in obesity.
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